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EXHIBIT ID: CI_C_0667

Normal Defense vs. Abnormal Defense in ITP

Normal Defense vs. Abnormal Defense in ITP

This illustration shows the comparison between a normal immune defense and an abnormal immune defense in a patient with immune thrombocytopenia (ITP). The normal immune defense shows a macrophage in the spleen using antibodies to identify and attack bacteria that has entered the body. The abnormal defense in a patient with ITP displays a macrophage in the spleen using autoantibodies to mistakenly attack the platelets of the body.